Abstract
Mycophenolic acid (MPA), known as an inhibitor of inosine monophosphate dehydrogenase (IMPDH), was found to inhibit the differentiation of 3T3-L1 pre-adipocytes into mature adipocytes. Although the effect of MPA was attributed to inhibition of IMPDH, we uncovered a hidden biological property of MPA as an agonist of peroxisome proliferator activated receptor gamma (PPARgamma).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3T3-L1 Cells
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Animals
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Cell Differentiation
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Cell Line, Tumor
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Chemistry, Pharmaceutical / methods
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Dose-Response Relationship, Drug
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Drug Design
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Humans
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Ligands
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Mice
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Models, Chemical
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Mycophenolic Acid / pharmacology*
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PPAR gamma / agonists*
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PPAR gamma / metabolism*
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Structure-Activity Relationship
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Time Factors
Substances
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Ligands
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PPAR gamma
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Mycophenolic Acid